Left ventricular resynchronization therapy in a canine model of left bundle branch block.

Cine DENSE MRI detects delayed mechanical activation of the left ventricular free wall in a canine model of heart failure with left bundle branch block

Background Cardiac resynchronization therapy (CRT) benefits selected heart failure patients; however, CRT has a nonresponse rate of approximately 30-40%. Important factors that contribute to lead placement decisions and overall CRT success include determination of mechanical dyssynchrony, presence and location of scar, and the identification of late-activated segments. Recent imaging studies ha...

Left ventricular endocardial pacing improves resynchronization therapy in canine left bundle-branch hearts.

BACKGROUND We investigated the benefits of the more physiological activation achieved by left ventricular (LV) endocardial pacing (ENDO) as compared with conventional epicardial (EPI) LV pacing in cardiac resynchronization therapy. METHODS AND RESULTS In 8 anesthetized dogs with experimental left bundle-branch block, pacing leads were positioned in the right atrium, right ventricle, and at 8 ...

Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch block.

Experimental studies have shown that biventricular pacing can improve systolic function in the failing heart with bundle branch block. The goal of this study was to develop and validate a three-dimensional computational model of the dilated failing heart with left bundle branch block to investigate how biventricular pacing can improve systolic mechanical performance and synchrony. In an anatomi...

Cardiac resynchronization therapy for heart failure induced by left bundle branch block after transcatheter closure of ventricular septal defect

A 54-year-old female patient with congenital heart disease had a persistent complete left bundle branch block three months after closure by an Amplatzer ventricular septal defect occluder. Nine months later, the patient suffered from chest distress, palpitation, and sweating at daily activities, and her 6-min walk distance decreased significantly (155 m). Her echocardiography showed increased l...

Does cardiac resynchronization therapy benefit patients with right bundle branch block: left ventricular free wall pacing: seldom right for right bundle branch block.